2010 - 2011 Detroit Pistons Schedule
October 2010
| Date | Opponent | Time |
| Tue, Oct 5 | at Miami Heat (P) | 7:30 pm |
| Fri, Oct 8 | Milwaukee Bucks (P) | 7:30 pm |
| Mon, Oct 11 | Atlanta Hawks (P) | 7:30 pm |
| Wed, Oct 13 | Dallas Mavericks (P) | 7:00 pm |
| Fri, Oct 15 | at Minnesota Timberwolves (P) | 7:30 pm |
| Sat, Oct 16 | at Charlotte Bobcats (P) | 6:30 pm |
| Tue, Oct 19 | Washington Wizards (P) | 7:00 pm |
| Fri, Oct 22 | Memphis Grizzlies (P) | 7:30 pm |
| Wed, Oct 27 | at New Jersey Nets | 7:00 pm |
| Fri, Oct 29 | Oklahoma City Thunder | 8:00 pm |
| Sat, Oct 30 | at Chicago Bulls | 8:00 pm |
November 2010
| Date | Opponent | Time |
| Tue, Nov 2 | Boston Celtics | 7:30 pm |
| Wed, Nov 3 | at Atlanta Hawks | 7:00 pm |
| Fri, Nov 5 | Charlotte Bobcats | 7:30 pm |
| Sun, Nov 7 | Golden State Warriors | 6:00 pm |
| Tue, Nov 9 | at Portland Trail Blazers | 10:00 pm |
| Fri, Nov 12 | at Los Angeles Clippers | 10:30 pm |
| Sun, Nov 14 | at Sacramento Kings | 6:00 pm |
| Mon, Nov 15 | at Golden State Warriors | 10:30 pm |
| Wed, Nov 17 | Los Angeles Lakers | 7:30 pm |
| Sun, Nov 21 | Washington Wizards | 6:00 pm |
| Tue, Nov 23 | at Dallas Mavericks | 8:30 pm |
| Wed, Nov 24 | at Memphis Grizzlies | 8:00 pm |
| Fri, Nov 26 | Milwaukee Bucks | 7:30 pm |
| Sun, Nov 28 | New York Knicks | 1:30 pm |
| Tue, Nov 30 | at Orlando Magic | 7:00 pm |
December 2010
| Date | Opponent | Time |
| Wed, Dec 1 | at Miami Heat | 7:30 pm |
| Fri, Dec 3 | Orlando Magic | 7:30 pm |
| Sun, Dec 5 | Cleveland Cavaliers | 6:00 pm |
| Tue, Dec 7 | at Houston Rockets | 8:30 pm |
| Wed, Dec 8 | at New Orleans Hornets | 8:00 pm |
| Fri, Dec 10 | at Minnesota Timberwolves | 8:00 pm |
| Sat, Dec 11 | Toronto Raptors | 7:30 pm |
| Tue, Dec 14 | Atlanta Hawks | 7:30 pm |
| Fri, Dec 17 | Los Angeles Clippers | 7:30 pm |
| Sun, Dec 19 | New Orleans Hornets | 6:00 pm |
| Wed, Dec 22 | at Toronto Raptors | 7:00 pm |
| Sun, Dec 26 | Chicago Bulls | 6:00 pm |
| Mon, Dec 27 | at Charlotte Bobcats | 7:00 pm |
| Wed, Dec 29 | Boston Celtics | 7:30 pm |
| Fri, Dec 31 | at Phoenix Suns | 9:00 pm |
January 2011
| Date | Opponent | Time |
| Mon, Jan 3 | at Utah Jazz | 9:00 pm |
| Tue, Jan 4 | at Los Angeles Lakers | 10:30 pm |
| Sat, Jan 8 | Philadelphia 76ers | 7:30 pm |
| Mon, Jan 10 | at Chicago Bulls | 8:00 pm |
| Wed, Jan 12 | Memphis Grizzlies | 7:30 pm |
| Fri, Jan 14 | at Toronto Raptors | 7:00 pm |
| Sat, Jan 15 | Sacramento Kings | 7:30 pm |
| Mon, Jan 17 | Dallas Mavericks | 3:30 pm |
| Wed, Jan 19 | at Boston Celtics | 7:30 pm |
| Fri, Jan 21 | at New Jersey Nets | 7:00 pm |
| Sat, Jan 22 | Phoenix Suns | 7:30 pm |
| Mon, Jan 24 | at Orlando Magic | 7:00 pm |
| Wed, Jan 26 | Denver Nuggets | 7:30 pm |
| Fri, Jan 28 | at Miami Heat | 7:30 pm |
| Sun, Jan 30 | at New York Knicks | 7:30 pm |
February 2011
| Date | Opponent | Time |
| Wed, Feb 2 | Charlotte Bobcats | 7:30 pm |
| Fri, Feb 4 | New Jersey Nets | 7:30 pm |
| Sat, Feb 5 | at Milwaukee Bucks | 8:30 pm |
| Tue, Feb 8 | San Antonio Spurs | 7:30 pm |
| Wed, Feb 9 | at Cleveland Cavaliers | 7:00 pm |
| Fri, Feb 11 | Miami Heat | 7:30 pm |
| Sun, Feb 13 | Portland Trail Blazers | 6:00 pm |
| Mon, Feb 14 | Atlanta Hawks | 7:30 pm |
| Wed, Feb 16 | Indiana Pacers | 7:30 pm |
| Tue, Feb 22 | Houston Rockets | 7:30 pm |
| Wed, Feb 23 | at Indiana Pacers | 7:00 pm |
| Fri, Feb 25 | at Philadelphia 76ers | 7:00 pm |
| Sat, Feb 26 | Utah Jazz | 7:30 pm |
March 2011
| Date | Opponent | Time |
| Tue, Mar 1 | at Milwaukee Bucks | 8:00 pm |
| Wed, Mar 2 | Minnesota Timberwolves | 7:30 pm |
| Sun, Mar 6 | Washington Wizards | 6:00 pm |
| Wed, Mar 9 | at San Antonio Spurs | 8:30 pm |
| Fri, Mar 11 | at Oklahoma City Thunder | 8:00 pm |
| Sat, Mar 12 | at Denver Nuggets | 9:00 pm |
| Wed, Mar 16 | Toronto Raptors | 7:30 pm |
| Fri, Mar 18 | New York Knicks | 7:30 pm |
| Sun, Mar 20 | at Atlanta Hawks | 2:00 pm |
| Wed, Mar 23 | Miami Heat | 7:30 pm |
| Fri, Mar 25 | at Cleveland Cavaliers | 7:30 pm |
| Sat, Mar 26 | Indiana Pacers | 7:30 pm |
| Wed, Mar 30 | at Indiana Pacers | 7:00 pm |
April 2011
| Date | Opponent | Time |
| Fri, Apr 1 | Chicago Bulls | 7:30 pm |
| Sun, Apr 3 | at Boston Celtics | 6:00 pm |
| Tue, Apr 5 | at Washington Wizards | 7:00 pm |
| Wed, Apr 6 | New Jersey Nets | 7:30 pm |
| Fri, Apr 8 | Milwaukee Bucks | 7:30 pm |
| Sun, Apr 10 | at Charlotte Bobcats | 6:00 pm |
| Mon, Apr 11 | Cleveland Cavaliers | 7:30 pm |
| Wed, Apr 13 | at Philadelphia 76ers | 8:00 pm |
